Biologic Properties of Hepatitis B Viral Genomes with Mutations in the Precore Promoter and Precore Open Reading Frame
نویسندگان
چکیده
منابع مشابه
Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame.
It is now well recognized that mutations in the hepatitis B virus (HBV) genome occur during the natural course of chronic viral infection. Regions of the viral genome that are frequently affected by such mutations, rearrangements, and/or deletions generally involve the precore promoter, precore, and core as well as the preS gene regions. However, little is known regarding the biologic consequen...
متن کاملMutations of Basal Core Promoter and Precore Regions in Hepatitis B Virus Genotypes B and C
BACKGROUND Mutations in basal core promoter (BCP) and precore regions of hepatitis B virus (HBV) are associated with course and treatment outcomes of chronic HBV infection. While BCP and precore mutation analysis have been carried out in adult patients between different genotypes, this analysis has rarely been performed for chronically infected children. OBJECTIVES The aim of this study was t...
متن کاملHigh rate of core promoter and precore mutations in patients with chronic hepatitis B
BACKGROUND The prevalence of precore (PC) and core promoter (CP) mutations in patients with chronic hepatitis B virus (HBV) infection (CHB) and their impact on liver disease is incompletely defined in the United States. METHODS A retrospective chart review using a cross-sectional approach of 1,186 CHB patients was conducted. RESULTS Of 926 patients tested for HBV e antigen (HBeAg), 37% were...
متن کاملMutations in the Basal Core Promoter and Precore/Core Regions of Hepatitis B Virus in Patients Co-Infected With Human Immunodeficiency Virus
ABSTRACT Background and objectives: Globally, about one third of the population has been infected with Hepatitis B virus (HBV) and more than 400 million people have become chronically infected. Nearly, 20-25% of all carriers develop serious liver diseases such as cirrhosis, chronic hepatitis and hepatocellular carcinoma (HCC). According to t...
متن کاملmutations of basal core promoter and precore regions in hepatitis b virus genotypes b and c
conclusions the mutation ratio difference between genotypes b and c in children was higher than that of adults and several combined mutations were exclusively detected in children with chronic hbv genotype c infection associated with higher viral load. objectives the aim of this study was to assess the mutation profiles of bcp and precore regions in different hbv genotypes in chronically infect...
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ژورنال
عنوان ژورنال: Virology
سال: 1997
ISSN: 0042-6822
DOI: 10.1006/viro.1997.8594